Keith Earls has been ruled out of the Ireland squad for their summer tour to New Zealand and Australia joining O'Connell, Best and McLaughlin on the injured list.
Earls has been suffering from a persistent groin injury and following his participation in the training camp in Limerick this week he has been ruled out of the tour.
Connacht's Gavin Duffy, who was been named in the Ireland XV for the game against the Barbarians in Thomond Park on Friday night, will now travel with the squad to New Zealand in place of Earls.
Ireland had already lost British and Irish Lions captain Paul O'Connell,Rory Best and Kevin McLaughlin for the duration of the tour.
IRELAND Squad (2010 Summer Tour, June 4-June 26):
Backs (15) -
Tommy Bowe (Ospreys)
Gordon D'Arcy (Lansdowne/Leinster)
Gavin Duffy (Galwegians/Connacht)
Shane Horgan (Boyne/Leinster)
Rob Kearney (UCD/Leinster)
Fergus McFadden (Old Belvedere/Leinster)*
Geordan Murphy (Leicester Tigers)
Brian O'Driscoll (UCD/Leinster)
Ronan O'Gara (Cork Constitution/Munster)
Tomas O'Leary (Dolphin/Munster)
Eoin Reddan (Lansdowne/Leinster)
Jonathan Sexton (St. Mary's College/Leinster)
Peter Stringer (Shannon/Munster)
Andrew Trimble (Ballymena/Ulster)
Paddy Wallace (Ballymena/Ulster)
Forwards (18) -
Tony Buckley (Shannon/Munster)
Tom Court (Malone/Ulster)
Sean Cronin (Buccaneers/Connacht)
Jerry Flannery (Shannon/Munster)
John Fogarty (De La Salle Palmerston/Leinster)*
John Hayes (Bruff/Munster)
Cian Healy (Clontarf/Leinster)
Jamie Heaslip (Naas/Leinster)
Chris Henry (Ballymena/Ulster)*
Marcus Horan (Shannon/Munster)
Shane Jennings (St. Mary's College/Leinster)
John Muldoon (Galwegians/Connacht)
Donncha O'Callaghan (Cork Constitution/Munster)
Mick O'Driscoll (Cork Constitution/Munster)
Ed O'Donoghue (Ballynahinch/Ulster)*
Niall Ronan (Shannon/Munster)
Dan Tuohy (Ballymena/Ulster)*
David Wallace (Garryowen/Munster)
* Denotes uncapped player
Tour Match Schedule:
Friday, June 4: Barbarians v Ireland XV, Thomond Park, 7.45pm
Saturday, June 12: New Zealand v Ireland, Yarrow Stadium, New Plymouth, 7.35pm (8.35am Irish time)
Friday, June 18: New Zealand Maori v Ireland XV, International Stadium, Rotorua, 7.35pm (8.35am Irish time)
Saturday, June 26: Australia v Ireland, Suncorp Stadium, Brisbane, 8pm (11am Irish time)
